Notifications
Clear all

Aspirin – the original Longevity wonder drug  


GnomeBe
Posts: 36
Admin
(@gnomebe)
Member
Joined: 1 year ago
Aspirin – the original Longevity wonder drug
 

Aspirin could reduce healthcare spending by nearly $700 billion in the US alone – and it’s already in mass-production.

Acetylsalicylic acid, originally extracted from willow bark, was first dispensed as medicine in 1899 [1] and has gone from strength to strength as ‘aspirin’ ever since; it even has a World Record for the being the most frequently-sold painkiller [2] with Americans alone consuming 80 million pills annually [3].

Asprin started life as a pain killer and anti-inflammatory but has been found to help prevent certain cancers (reduction of 73% decrease in oesophageal cancer, 63% for colon cancer, 62% for stomach cancer, 47% for ovarian cancer 39% for breast and prostate cancers and 36% for lung cancer) [4]. It is used to prevent strokes and aid stroke recovery, treat hypertension, and prevent heart attacks and thrombosis. The latest research shows that aspirin could be used to treat Alzheimer’s disease [5] and cataracts [6].

Longevity.Technology: The benefits of aspirin seem huge – one little tablet can go a long way. We think it’s great that so much research is going into a drug that has such a weight of clinical data and years of testing by the public behind it. Aspirin is cheap to manufacture and the mechanisms for doing so are widely available; if one of the keys to Longevity turned out to be something we had all along, the long life would be available for the masses. From willow bark to will o’ the people.

The TRL score for this Longevity. Technology domain is currently set at: ‘Technology has completed initial trials and demonstrates preliminary safety data.’

The TRL score for the technology addressed in this article is: “Technology refined and ready for initial human trials.’

New medical uses for aspirin are being researched and discovered all the time. Paul Lietman, when he was a professor of pharmacology at the Johns Hopkins Medical Institutions in Baltimore, said: “Is mind-boggling how many new applications this simple drug has; it seems that each year we hear of a new therapeutic application for the drug.” [7]

These are all broad brush strokes on the Longevity canvas, but is aspirin itself capable of delaying aging? When there was no common thread linking the benefits of aspirin together, pharmacologist John Vane, researching at the University of London, discovered that aspirin is able to inhibit the formation of prostaglandins, powerful chemicals in the body which are synthesized from fatty acids in all the cells in our bodies except red blood cells.

Although prostaglandins play an essential role in a variety of functions such as muscle contraction, dilation and constriction of blood vessels, and ovulation, they are also released when a cell is damaged or stimulated, causing tissue damage.

Research into aspirin and prostaglandins earned John Vane a Knighthood and along with fellow researchers Sune Bergström and Bengt Samuelsson, a Nobel Prize. Research has found that prostaglandins inhibit or stimulate the molecules released by dying cells called damage-associated molecular patterns (DAMPs); understanding this pathway will allow researchers to control inflammation and possibly prevent certain types of cell death [8].

It’s not just the “wrong sort” of prostaglandins on which aspirin can work its magic; aspirin has been proven to affect oxidant production and mop up damaging reactive oxygen species, affect cytokine responses and to be able to block glycoxidation reactions, leading researchers to describe it as posing a “triple threat against the symptoms of aging” [9]. Other research has shown that aspirin can protect telomeres during cell reproduction, preventing their shortening and associated cell aging and death [10].

With seemingly multitude benefits, it’s no wonder researchers decided to find out what the long-term effects on Longevity and healthcare costs would be if apirin use were more widespread. Looking at data from people in the US aged 51 to 79, researchers found that over a 20-year period, regular aspirin medication would prevent 11 cases of heart disease and four cases of cancer in every 1000 people, increase life expectancy by four months, meaning an extra 900,000 people would be alive in 2036 and save the US economy $695 billion [11].

Four months is a start, but it’s not Longevity. Further studies are being conducted, using US and Australian data and both ASPREE (ASPirin in Reducing Events in the Elderly, looking at increased survival that is free of dementia and physical disability) and ASPREE-XT (eXTension, investigating the health outcomes for cancer, dementia, frailty and other conditions of aging, over a longer period of time) are focusing on using the benefits of aspirin to both prolong life and prolong healthy life [12].

Research on use of aspirin for the elderly is necessary; it is difficult to find a wealth of data for an older population, as many already have existing conditions. New guidelines published last year in the US recommending against routinely giving aspirin to older adults (70+) who don’t have a history of heart disease due to an increased risk of brain bleeds [13] – there aren’t the pro-aspirin figures to weigh the negative impacts up against.

[1]  https://www.aspirin.com/en/about-aspirin/history/
[2]  https://www.guinnessworldrecords.com/
[3]  https://www.encyclopedia.com/medicine/drugs/pharmacology/aspirin
[4]  https://www.ncbi.nlm.nih.gov/pubmed/15756426
[5]  https://bit.ly/2Mp5Hbw
[6]  https://www.ncbi.nlm.nih.gov/pubmed/1993037
[7]  https://wapo.st/2TGMjHO
[8]  https://www.pnas.org/content/113/14/3844
[9] https://www.ncbi.nlm.nih.gov/pubmed/15671726
[10]  https://www.leafscience.org/aggregator/sens5-aspirin-the-oldest-new-anti-aging-drug/
[11]  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166103
[12]  https://aspree.org/
[13]  https://www.aarp.org/health/drugs-supplements/info-2019/warnings-on-daily-aspirin.html
Image: Icatnews / Shutterstock.com
Reply
Share:

Join Us!

Psychedelic Therapy:

Psychedelic Drug Psilocybin Tamps Down Brain’s Ego Center plus Getting Closer to Nature, One Bite at a Time

Psychedelic Drug Psilocybin Tamps Down Brain’s Ego Center plus Getting Closer to Nature, One Bite at a Time – Dr. Frederick Barrett – Steve Brill – Violet Brill – Perhaps no region of the brain is more fittingly named than the claustrum, taken from the Latin word for -hidden or shut away-. The claustrum is an extremely thin sheet of neurons deep within the cortex, yet it reaches out to every other region of the brain. Its true purpose remains -hidden away- as well, with researchers speculating about many functions. What is known is that this region contains a large number of receptors targeted by psychedelic drugs such as LSD or psilocybin the hallucinogenic chemical found in certain mushrooms. To see what happens in the claustrum when people are on psychedelics, Johns Hopkins Medicine researchers compared the brain scans of people after they took psilocybin with their scans after taking a placebo. PLUS Steve and Violet Brill looks at a forest the same way most people think about a supermarket. Walkthrough a park or wooded area with them and they can show you a number of wild plants that might make for tasty additions to your dinner plate. They would tell you how yellow wood sorrel tastes just like lemonade or how black birch can be used as a minty flavoring for pudding. With the advent of this pandemic, foraging may be more important than ever. Some are including it in their home-schooling curriculum in hopes of arming their children with this almost-forgotten art.

Longevity – Life Extension – Anti-Aging Board

LONGEVITY MEDICINE:

THE CURRENT FRONTIER IN MEDICINE IS LONGEVITY MEDICINE BECAUSE IT’S PREVENTIVE & FOR EVERYONE WHO WANTS TO PREVENT A MEDICAL ISSUE NATURALLY – EVEN USING SYNTHETIC SUBSTANCES – TO PREVENT AGING & ENCOURAGE HEALTH & WELLBEING.

“An ounce of prevention is worth a pound of cure.”

OBJECTIVES

OPEN DISCUSSION / ANTI-AGING -RESOURCE BOARD THAT WILL NEVER DIE


Peptides – a Powerful Piece of the Longevity Puzzle

In this episode of Living Beyond 120, Mark and Dr. Gladden begin by talking about how we need to manifest goals in our minds first in order to make them realities.

Next, they discuss some recent health tests Dr. Gladden participated in, along with the remarkable results regarding his cardiovascular health and age. He talks about his plans for getting in the best shape of his life.

They continue their conversation revisiting the subject of peptides, discussing specific peptides, and the amazing outcomes that Dr. Gladden is seeing in his practice. From better immune function to healing the gut, improved fat burning, and much more, they describe which peptides have had positive health effects on many different conditions. To learn more about peptides, you can visit https://tailormadecompounding.com/.

WHY DOES COVID-19 KILL SOME PEOPLE & SPARE OTHERS WITH TED RYCE

The novel coronavirus causing COVID-19 seems to hit some people harder than others, with some people experiencing only mild symptoms and others being hospitalized and requiring ventilation. In this episode, Ted shares the latest research on the coronavirus.

Preventing Cardiovascular Disease – an Interview with Dr. Jeffry Life 

In this episode, we’re featuring a special RAAD Fest discussion from last year between Dr. Gladden and Dr. Jeffry Life, a doctor who has focused his practice on healthy aging and helping patients avoiding heart attacks and strokes. He incorporates the Bale-Doneen Method (learn more in the book Beat the Heart Attack Gene) in his treatment plans, which is about aggressively looking for vascular inflammation that causes heart disease and working to stop it.

They discuss some of the testings that can be done to identify vascular risk factors, which fall outside of the normal insurance-based model of healthcare.

Ketogenic Diet Hacks:

Doing The Perfect Keto Diet: Doing Perfect Keto – Chris Irvin –

Everyone agrees that a low-carb, low-sugar Keto lifestyle reduces inflammation and resets insulin sensitivity. Yet there is still confusion about what to eat too and what not to eat. So much so there are entire books dedicated to the subject. And much of that information in those books become outdated as soon as new research provides insights into which foods and supplements work or don’t work as originally expected. And when it comes to snack foods and sweet treats the water gets even murkier. What if there was a website that was driven by current science and gave you access to everything you needed to do low-carb Keto right? Perfect Keto.

RSS Live Long and Master Aging

  • #203 Health Starts In Your Mouth - Dr Dominik Nischwitz September 21, 2020
    Welcome to the Body Mind Empowerment podcast I’m your host Siim Land and our guest today is Dr Dominik Nischwitz. Dr Dome is a biological dentist and functional medical practitioner in Germany. He’s written the book It's All In Your Mouth and practices biological dentistry in his clinic. Timestamps: What Is Biological Dentistry 01:30 How […]
    Siim Land
  • #202 Birthday Q&A - Hair Health, Fixing Tendonitis, Preventing Neurodegeneration September 17, 2020
    This episode is a live Q&A on Siim's birthday. Timestamps: How to Improve HDL Cholesterol 01:53 Astragalus and Autophagy Boosters 02:55 Hair Health and Growth 04:29 How to Detox Regularly 05:53 Tips for Giving Up Caffeine 09:14 Siim's Current Food Protocol 10:48 Can Autophagy Fight the Virus 14:14 How to Treat Acne and Improve Skin […]
    Siim Land
  • #201 Molecular Hydrogen, Oxidative Stress, and Autophagy - Tyler LeBaron September 14, 2020
    Welcome to the Body Mind Empowerment Podcast I’m your host Siim Land and our guest today is Tyler LeBaron. Tyler is the founder and executive director of the Molecular Hydrogen Institute. He’s the world’s leading expert on molecular hydrogen and how it can affect health, aging, and stress resilience. Get Drink HRW Molecular Hydrogen for […]
    Siim Land
  • #200 Optimal Meal Timing and Circadian Rhythms - Siim Land at the Biohacker Summit 2019 September 12, 2020
    In this episode, you can listen to Siim Land's speech at the Biohacker Summit 2019 in Helsinki. It talks about optimal meal timing, circadian rhythms, and intermittent fasting. Click here to watch it on YouTube! Here are the links to the podcast on all platforms Link to the Audio Podcast on iTunes and Stitcher Link to the podcast […]
    Siim Land
  • #199 Why You Need More Magnesium to Manage Stress - Wade Lightheart September 6, 2020
    Welcome to the Body Mind Empowerment Podcast I’m your host Siim Land and our guest today is Wade Lightheart. Wade is one of the founders of BiOptimizers, which is a supplement company that fixes digestion. He’s also a Canadian natural bodybuilding champion. We’re going to talk about stress and magnesium. Timestamps: How Wade Reacted to […]
    Siim Land
  • #198 Stronger by Stress Q&A with Teemu Arina August 30, 2020
    In this episode of the Body Mind Empowerment Podcast we talk about my new book Stronger by Stress. It's recorded at the Biohacker Center with Teemu Arina. Timestamps: Introduction Notes 00:48 Siim's Time During the Lockdown 04:04 Hormesis and Antifragility 07:00 How to Lower Chronic Stress 10:35 Break Vicious Cycles of Stress 13:40 Gut Problems […]
    Siim Land
  • #197 Genetics for Weight Loss and Longevity - Joe Cohen August 25, 2020
    Welcome to the Body Mind Empowerment Podcast, I’m your host Siim Land and our guest today is Joe Cohen. Joe is the founder and CEO of Self-Hacked, which is one of the most popular biohacking websites online. He’s also founded SelfDecode, which is a genetics decoding company.   Timestamps: How Joe Started to Research Genetics […]
    Siim Land
  • #196 Neurohacking the Brain and Stress - Dr Greg Kelly August 19, 2020
    Welcome to the Body Mind Empowerment Podcast I’m your host Siim Land and our guest today is Dr Gregory Kelly. Dr Greg is a naturopathic physician and former editor of the journal Alternative Medicine Review. He’s also a lead product formulator at Neurohacker Collective. Timestamps: Greg's Background as an ND and the Army 02:10 Neurohacking […]
    Siim Land
  • #195 Continuous Glucose Monitoring for Better Metabolic Health - Kara Collier August 13, 2020
    Welcome to the Body Mind Empowerment Podcast I’m your host Siim Land and our guest today is Kara Collier. Kara is the Head of Nutrition at Nutrisense.io, which is a company that offers commercial continuous glucose monitoring services. Your glucose is one of the best indicators of overall metabolic health and flexibility. I also tried […]
    Siim Land
  • #194 Stoicism and the Art of Happiness - Donald Robertson August 5, 2020
    Welcome to the Body Mind Empowerment Podcast I’m your host Siim Land and our guest today is Donald Robertson. Donald is a writer about stoic philosophy and an expert in cognitive behavioral therapy. He’s written several books like How to Think Like a Roman Emperor and Stoicism and the Art of Happiness. Timestamps: How Donald […]
    Siim Land
  • #193 How to Stay Healthy in a City - Tim Gray July 31, 2020
    Welcome to the Body Mind Empowerment Podcast I’m your host Siim Land and our guest today is Tim Gray. Tim is an entrepreneur and biohacker from the UK. He’s also the founder of the Health Optimisation Summit in London. We’re going to talk about how to stay healthy and well when living in urban environments […]
    Siim Land
  • #192 Dr Dominic D’Agostino on Using Ketosis for High Stress Environments July 25, 2020
    Welcome to the Body Mind Empowerment podcast I’m your host Siim Land and our guest today is Dr Dominic D’Agostino. Dr Dom has a PhD in neuroscience and physiology. He’s a professor at the University of South Florida and is considered one of the world’s top experts in ketosis, ketogenic diets, fasting, and hyperbaric oxygen […]
    Siim Land
  • #191 Biohacking Focus, Productivity and Performance with Olli Sovijärvi and Teemu Arina July 19, 2020
    Welcome to the Body Mind Empowerment Podcast I’m your host Siim Land and our guests today are Olli Sovijärvi and Teemu Arina. Olli and Teemu run the Biohacker Center in Finland and organize the Biohacker Summit. In this episode we’re going to talk about how to optimize your health and performance at work, especially if […]
    Siim Land
  • #190 How to Swap Out Bad Fats From Your Body with Dave Asprey July 12, 2020
    Welcome to the Body Mind Empowerment Podcast. I’m your host Siim Land and our guest today is Dave Asprey. Dave is the founder of Bulletproof, Truedark, and many other companies. He’s a best-selling author of several books and often called the ’father of biohacking’. Timestamps: Biohacking and Medical Freedom 03:20 Bulletproof Coffee and Structured Water […]
    Siim Land
  • #189 Lower Inflammation and Pain Using PEMF Therapy with Bob Dennis PhD July 6, 2020
    Welcome to the Body Mind Empowerment Podcast I’m your host Siim Land and our guest today is Bob Dennis. Bob has a PhD in Biomedical Engineering. He’s one of the first people to use Pulsed Electromagnetic Frequency (PEMF) therapy in NASA. During the 90s he worked with NASA to build PEMF equipment for astronauts. Bob […]
    Siim Land

Please follow & like us :)