Much of the existing research on long-life centers on the aging system in a single model. Several molecular players (e.g., IGF 1 and MTOR), pharmacological compounds (e.g., rapamycin and metformin), and nutritional strategies (e.g., calorie limitation and methionine limitation) are essential in managing and modestly extending lifespan in model organisms. Natural lifespan varies much more substantially across species. In creatures alone, the maximum lifespan differs greater than 100 fold; however, the underlying governing systems remain inadequately comprehended. Recent research studies are beginning to shed light on the molecular signatures related to remarkable longevity. These include genome sequencing of microbats, naked mole-rat, blind mole rat, bowhead whale, and African turquoise killifish, and relative evaluations of gene expression, metabolites, lipids, and ions throughout numerous mammalian species. With each other, they direct in various suppositional approaches for lifespan guidelines as well as cancer resistance, in addition to the paths and metabolites connected with a long life variant. Correctly, long life may be accomplished by both lineage-specific adjustments and usual devices that use throughout the types. Comparing the resulting cross-species molecular signs with the within-species lifespan extension approaches will undoubtedly boost our understanding of mechanisms of long life control and offer a starting point for novel and efficient interventions.