Aging, as a physical system governed by numerous regulatory paths and transcription elements. There is an increasing enthusiasm to find medicinal agents for therapy and prevention of age-related illness in human beings. Animal models play a vital role in the recognition and testing of anti-aging substances; this action is crucial before the medication will go into human medical trials or will be introduced to human medicine. Amongst the goals of animal research studies are a much better understanding of mechanistic targets, healing results, and side-effects of the drug, which might be later related to individuals. In this phase, we summed up the impacts of different medications reported extending the life span in design bacteria from rounded worms to rats. Resveratrol, rapamycin, metformin, and aspirin, revealing, effectiveness in style microbe life- and healthspan expansion more targets the master regulators of aging such as mTOR, FOXO and PGC1α, affecting autophagy, swelling and oxidative stress and anxiety. In people, these medications were shown to reduce swelling, prevent CVD, and lower the practical decrease in specific organs. Additionally, potential anti-aging pharmacologic representatives prevent cancerogenesis, interfering with particular aspects of cell metabolic processes, expansion, angiogenesis, and apoptosis.