Methylxanthines (MTXs) are taken in by nearly everyone in almost every location of the world. Caffeine, theophylline, and also theobromine are the most well‐known participants of this family of substances; they exist in coffee, tea, cacao, Yerba Mate', as well as soda pop beverages. MTXs are conveniently absorbed in the stomach tract and have the ability to permeate right into the central nervous system, where they put in substantial psychostimulant activities, which are more apparent in the intense intake. Coffee has actually been paradigmatic, as its use was prohibited in lots of diseases, however, this adverse view has actually radically transformed; evidence shows that MTXs show health advantages in illness involving cell death in the nerve system. This paper examines data that assess the preventative and also restorative potential of MTXs in a range of neurodegenerative conditions. Future viewpoints consist of using MTXs to advance the comprehending the pathophysiology of, inter alia, Alzheimer's and also Parkinson's disease(PD), as well as making use of the methylxanthine chemical moiety as a basis for the development of brand-new and also extra effective drugs.