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Effect of Ursolic Acid on Metabolic Syndrome, Insulin Sensitivity, and Inflammation  

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Ursolic acid (UA) is a pentacyclic triterpene which is located alike natural herbs and also medicinal plants that are deemed for a range of medicinal effects. Both as an energetic principle of these plants and also as a nutraceutical component, the pharmacology of UA in the CNS and other body organs as well as systems have actually been extensively reported in recent times. In this interaction, the antioxidant, as well as the anti-inflammatory axis of UA's pharmacology, is evaluated for its therapeutic potential in some typical CNS problems. Classic instances consist of traumatic mind injury (TBI), cerebral anaemia, cognition shortage, anxiousness, and also clinical depression. The pharmacological efficacy for UA is demonstrated through the healing principle of one/ lots of conditions (s). Both details enzymes as well as receptor targets along with diverse pharmacological effects connected with oxidative anxiety as well as inflammatory signalling are scrutinised.


Journal of Medicinal Food VOL. 20, NO. 9 |

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Effect of Ursolic Acid on Metabolic Syndrome, Insulin Sensitivity, and Inflammation

Published Online:

To evaluate the effect of ursolic acid on metabolic syndrome, insulin sensitivity, and inflammation, a randomized, double-blind, placebo-controlled clinical trial was carried out in 24 patients (30–60 years) with a diagnosis of metabolic syndrome without treatment. They were randomly assigned to two groups of 12 patients, each to receive orally 150 mg of ursolic acid or homologated placebo once a day for 12 weeks. Before and after the intervention, the components of metabolic syndrome, insulin sensitivity (Matsuda index), and inflammation profile (interleukin-6 and C-reactive protein) were evaluated. After ursolic acid administration, the remission of metabolic syndrome occurred in 50% of patients (P = .005) with significant differences in body weight (75.7 ± 11.5 vs. 71 ± 11 kg, P = .002), body mass index (BMI) (29.9 + 3.6 vs. 24.9 ± 1.2 kg/m2, P = .049), waist circumference (93 ± 8.9 vs. 83 + 8.6 cm, P = .008), fasting glucose (6.0 ± 0.5 vs. 4.7 ± 0.4 mmol/L, P = .002), and insulin sensitivity (3.1 ± 1.1 vs. 4.2 ± 1.2, P = .003). Ursolic acid administration leads to transient remission of metabolic syndrome, reducing body weight, BMI, waist circumference and fasting glucose, as well as increasing insulin sensitivity.