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Advances in Cannabinoid Physiology and Pathology Research  

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A Clinician's Guide to Cannabinoid Science

Steven James

Medical marijuana and the promise of medical advances with cannabinoids is a controversial topic. This book provides clinicians with credible, peer-reviewed science to advise patients on the use of cannabinoids in practice. From the history of cannabis to the recent discoveries, chapters include the science of cannabinoids, changes in the legal and regulatory landscape, and the emerging area of endocannabinoids. The book differentiates approved cannabinoids from cannabis and medical marijuana and stimulates clinicians to think about the risks and benefits of these two drugs. It provides the factual background for clinicians to lead the discussion on the continued use of marijuana, ongoing areas of research, and future advances and development of new medications for treatment. An invaluable guide for all specialists in the pharmaceutical sciences, toxicologists, biochemists, neurologists, psychiatrists, addiction specialists, as well as primary care physicians, nurse practitioners, and regulators, and policymakers.

Provides historical context on the use of cannabis and the scientific discoveries related to cannabinoids, providing an insight into the ever-developing science of cannabinoids
The evaluation of peer-reviewed medical literature on cannabinoids increases clinician confidence in the scientific findings presented
Highlights the differences between approved cannabinoids and medical marijuana, improving understanding of the flood of information now available.

Recent Advances in Cannabinoid Physiology And Pathology ?

Anna N. Bukiya

The cannabinoid system plays a central role in a wide variety of physiological functions that touch upon cardiovascular, gastrointestinal, immune, and nervous systems. Cannabinoids also play a central role in developmental physiology, management of pain, and shaping of human behaviour. Recent movements towards the legalization of marijuana use have bolstered scientific interest in the cannabinoid field and led to research efforts that would unveil multi-faceted effects and mechanisms of cannabinoid presence in different organs and at various stages of development. This book summarizes the recent advances in the field of cannabinoid research at multiple levels of resolution. It spans from systemic effects of cannabinoids on development, physiological function, and prevalent pathophysiological conditions to mechanisms that govern cannabinoid interaction with their relevant protein targets at atomic resolution. This book will be of interest to a specialized audience in the fields of biochemistry, pharmacology, and developmental biology but also to a wider readership with an interest in general physiology and cannabinoid signalling in biological systems.

Cannabinoids in Health and Disease

Rosaria Meccariello and Rosanna Chianese

This book provides a comprehensive overview of current knowledge of cannabinoid activity in human physiology and points out the importance of the endocannabinoid system for the maintenance of human health and treatment of diseases. Each chapter has been organized with the aim to cover basic concepts in the modulation of the endocannabinoid system in both physiological and pathological conditions, thanks to the integration of data from experimental animal models and clinical observations. A special focus has been put on the medical use of cannabinoids and on the targeting of the endocannabinoid system as a new therapeutic strategy for the prevention and treatment of human diseases. Taken together, this book targets a wide audience of basic and clinical scientists, teachers, and students interested in gaining a better understanding of the field of cannabinoids.


Vincenzo Di Marzo

‘Cannabinoids’ is a broad term covering a group of natural products from Cannabis sativa, one of which locks on to specific receptors – protein molecules on the surface of cells – known as cannabinoid receptors. Over the past decades, scientists have found that cannabinoid receptors and their endogenous ligands, the endocannabinoids, are involved in a vast array of physiological functions, including helping to control brain activity, energy metabolism, heart function, the immune system, and even reproduction.

In Cannabinoids, Vincenzo Di Marzo has assembled contributions from international experts to provide the definitive guide to what continues to be a rapidly developing research field. After an introductory historical chapter, the book continues by looking at the biochemical, genetic, and molecular elements of cannabinoids, followed by chapters covering their role in health and disease.  The final chapter outlines the need for a new nomenclature to reflect the complex and multi-disciplinary nature of this area.